Functional properties of hemoglobin Rainier
نویسندگان
چکیده
منابع مشابه
Oxygen Equilibrium and Circular Dichroism of Hemoglobin-Rainier
The sulfhydryl titration of hemoglobin Rainier (wl32 146Tyr-‘Cys) suggests that the cysteine residue HC2(145)/3 forms a disulfide bridge with the cysteine F9(93)/3 of the same /3 chain. The oxygen equilibrium of Hb-Rainier compared with that of HbA exhibits diminished heme-heme interaction (n = 1.3-1.5), increased oxygen affinity, and a small Bohr effect. The absorption spectrum and the circula...
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Hemoglobin Rainier (beta(145) tyrosine-->histidine) is an abnormal hemoglobin associated with increased oxygen affinity, decreased heme-heme interaction, presence of a Bohr effect, and erythrocytosis, but without obvious clinical sequelae. Regulation of erythropoiesis was studied in affected members of families having either hemoglobin Rainier or Yakima, abnormal hemoglobins associated with ery...
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Hemoglobin Bethesda is a /3 chain variant of human hemoglobin in which histidine is substituted for tyrosine at position 145. From chemical and crystallographic studies, it has been postulated that the tyrosine normally found at this position is critical for the maintaince of a normal deoxy structure. Kinetic studies of the carbon monoxide and Rbutyl isocyanide binding reactions show that deoxy...
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Blood and stripped hemoglobin from Nelore cattle individuals were submitted to oxygen equilibrium experiments in both gasometric and spectrophotometric methods. No difference was detected in oxygen affinity and Bohr effect among Hb A, Hb B and Hb AB in experiments with both blood and stripped hemoglobin, in the presence and absence of the chloride ion. However, n values (Hill plots) were higher...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1972
ISSN: 0014-5793
DOI: 10.1016/0014-5793(72)80197-2